PoplarV1, Main, Exploration, bibRecord, 002366

Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis).

Identifieur interne : 002366 ( Main/Exploration ); précédent : 002365; suivant : 002367

Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis).

Auteurs : Kai Wang [République populaire de Chine] ; Jianglin Zhang [République populaire de Chine] ; Shun Ping [République populaire de Chine] ; Quanxin Ma [République populaire de Chine] ; Xuan Chen [République populaire de Chine] ; Hongzhuan Xuan [République populaire de Chine] ; Jinhu Shi [République populaire de Chine] ; Cuiping Zhang [République populaire de Chine] ; Fuliang Hu [République populaire de Chine]

Source :

Journal of ethnopharmacology [ 1872-7573 ] ; 2014.

RBID : pubmed:24882729

Descripteurs français

KwdFr :
- Animaux (MeSH), Anti-inflammatoires (administration et posologie), Anti-inflammatoires (isolement et purification), Anti-inflammatoires (pharmacologie), Cellules HEK293 (MeSH), Chine (MeSH), Chromatographie en phase liquide à haute performance (méthodes), Cytokines (métabolisme), Endotoxémie (anatomopathologie), Endotoxémie (traitement médicamenteux), Extraits de plantes (administration et posologie), Extraits de plantes (isolement et purification), Extraits de plantes (pharmacologie), Humains (MeSH), Inflammation (anatomopathologie), Inflammation (traitement médicamenteux), Lignée cellulaire (MeSH), Lipopolysaccharides (toxicité), Macrophages (effets des médicaments et des substances chimiques), Mâle (MeSH), Médiateurs de l'inflammation (métabolisme), Piégeurs de radicaux libres (isolement et purification), Piégeurs de radicaux libres (pharmacologie), Populus (composition chimique), Propolis (administration et posologie), Propolis (isolement et purification), Propolis (pharmacologie), Relation dose-effet des médicaments (MeSH), Souris (MeSH), Souris de lignée ICR (MeSH), Éthanol (composition chimique).
MESH :
- administration et posologie : Anti-inflammatoires, Extraits de plantes, Propolis.
- anatomopathologie : Endotoxémie, Inflammation.
- composition chimique : Populus, Éthanol.
- effets des médicaments et des substances chimiques : Macrophages.
- isolement et purification : Anti-inflammatoires, Extraits de plantes, Piégeurs de radicaux libres, Propolis.
- métabolisme : Cytokines, Médiateurs de l'inflammation.
- méthodes : Chromatographie en phase liquide à haute performance.
- pharmacologie : Anti-inflammatoires, Extraits de plantes, Piégeurs de radicaux libres, Propolis.
- toxicité : Lipopolysaccharides.
- traitement médicamenteux : Endotoxémie, Inflammation.
- Animaux, Cellules HEK293, Chine, Humains, Lignée cellulaire, Mâle, Relation dose-effet des médicaments, Souris, Souris de lignée ICR.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Animals (MeSH), Anti-Inflammatory Agents (administration & dosage), Anti-Inflammatory Agents (isolation & purification), Anti-Inflammatory Agents (pharmacology), Cell Line (MeSH), China (MeSH), Chromatography, High Pressure Liquid (methods), Cytokines (metabolism), Dose-Response Relationship, Drug (MeSH), Endotoxemia (drug therapy), Endotoxemia (pathology), Ethanol (chemistry), Free Radical Scavengers (isolation & purification), Free Radical Scavengers (pharmacology), HEK293 Cells (MeSH), Humans (MeSH), Inflammation (drug therapy), Inflammation (pathology), Inflammation Mediators (metabolism), Lipopolysaccharides (toxicity), Macrophages (drug effects), Male (MeSH), Mice (MeSH), Mice, Inbred ICR (MeSH), Plant Extracts (administration & dosage), Plant Extracts (isolation & purification), Plant Extracts (pharmacology), Populus (chemistry), Propolis (administration & dosage), Propolis (isolation & purification), Propolis (pharmacology).
MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Plant Extracts, Propolis.
- chemical , chemistry : Ethanol.
- chemical , isolation & purification : Anti-Inflammatory Agents, Free Radical Scavengers, Plant Extracts, Propolis.
- chemical , metabolism : Cytokines, Inflammation Mediators.
- chemical , pharmacology : Anti-Inflammatory Agents, Free Radical Scavengers, Plant Extracts, Propolis.
- chemical , toxicity : Lipopolysaccharides.
- geographic : China.
- chemistry : Populus.
- drug effects : Macrophages.
- drug therapy : Endotoxemia, Inflammation.
- methods : Chromatography, High Pressure Liquid.
- pathology : Endotoxemia, Inflammation.
- Animals, Cell Line, Dose-Response Relationship, Drug, HEK293 Cells, Humans, Male, Mice, Mice, Inbred ICR.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Propolis is used widely in a number of cultures as a folk medicine and is gaining wider recognition for its potential therapeutic use, due to its wide range of biological properties and pharmacological activities, especially its anti-inflammatory effects. Despite an increasing number of studies focused on the biological activities of propolis together with its botanical sources, studies on Chinese propolis are insufficient. This study was designed to investigate the anti-inflammatory properties of ethanol extracts from Chinese propolis (EECP) and poplar buds (EEPB) from Populus×canadensis Moench (Salicaceae family).

MATERIALS AND METHODS

Phytochemical analysis of EECP and EEPB was performed via total phenolic and flavonoid content measurements followed by high-performance liquid chromatography (HPLC) analysis. DPPH and ABTS free-radical scavenging methods were used to evaluate their anti-oxidant properties. The anti-inflammatory effects of EECP and EEPB were investigated in vitro by evaluating their modulating effects on the key inflammatory cytokines and mediators in LPS/IFN-γ co-stimulated RAW 264.7 cells and by measuring nuclear factor (NF)-κB activation in TNF-α or IL-1β stimulation HEK 293 cells using reporter gene assays. Their effects on acute inflammatory symptoms (LPS-induced endotoxemia and acute pulmonary damage) were also examined in mice.

RESULTS

EECP and EEPB exhibited strong free-radical scavenging activity and significant in vitro anti-inflammatory effects by modulating key inflammatory mediators of mRNA transcription, inhibiting the production of specific inflammatory cytokines, and blocking the activation of nuclear factor (NF)-κB. The administration of EECP and EEPB (25 and 100 mg/kg) provided significant protective effects by attenuating lung histopathological changes and suppressing the secretion of LPS-stimulated inflammatory cytokines, such as interleukin-6 (IL-6), IL-10, MCP-1, TNF-α and IL-12p70 production in endotoxemic mice.

CONCLUSIONS

The results presented here reveal the potent anti-inflammatory properties of Chinese propolis and poplar buds, and provide biological information for developing suitable substitute(s) for propolis in the prevention and treatment of inflammatory diseases.

DOI: 10.1016/j.jep.2014.05.037
PubMed: 24882729

Affiliations:

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Le document en format XML

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<term>Anti-Inflammatory Agents (administration & dosage)</term>
<term>Anti-Inflammatory Agents (isolation & purification)</term>
<term>Anti-Inflammatory Agents (pharmacology)</term>
<term>Cell Line (MeSH)</term>
<term>China (MeSH)</term>
<term>Chromatography, High Pressure Liquid (methods)</term>
<term>Cytokines (metabolism)</term>
<term>Dose-Response Relationship, Drug (MeSH)</term>
<term>Endotoxemia (drug therapy)</term>
<term>Endotoxemia (pathology)</term>
<term>Ethanol (chemistry)</term>
<term>Free Radical Scavengers (isolation & purification)</term>
<term>Free Radical Scavengers (pharmacology)</term>
<term>HEK293 Cells (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Inflammation (drug therapy)</term>
<term>Inflammation (pathology)</term>
<term>Inflammation Mediators (metabolism)</term>
<term>Lipopolysaccharides (toxicity)</term>
<term>Macrophages (drug effects)</term>
<term>Male (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred ICR (MeSH)</term>
<term>Plant Extracts (administration & dosage)</term>
<term>Plant Extracts (isolation & purification)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Populus (chemistry)</term>
<term>Propolis (administration & dosage)</term>
<term>Propolis (isolation & purification)</term>
<term>Propolis (pharmacology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Anti-inflammatoires (administration et posologie)</term>
<term>Anti-inflammatoires (isolement et purification)</term>
<term>Anti-inflammatoires (pharmacologie)</term>
<term>Cellules HEK293 (MeSH)</term>
<term>Chine (MeSH)</term>
<term>Chromatographie en phase liquide à haute performance (méthodes)</term>
<term>Cytokines (métabolisme)</term>
<term>Endotoxémie (anatomopathologie)</term>
<term>Endotoxémie (traitement médicamenteux)</term>
<term>Extraits de plantes (administration et posologie)</term>
<term>Extraits de plantes (isolement et purification)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Humains (MeSH)</term>
<term>Inflammation (anatomopathologie)</term>
<term>Inflammation (traitement médicamenteux)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Lipopolysaccharides (toxicité)</term>
<term>Macrophages (effets des médicaments et des substances chimiques)</term>
<term>Mâle (MeSH)</term>
<term>Médiateurs de l'inflammation (métabolisme)</term>
<term>Piégeurs de radicaux libres (isolement et purification)</term>
<term>Piégeurs de radicaux libres (pharmacologie)</term>
<term>Populus (composition chimique)</term>
<term>Propolis (administration et posologie)</term>
<term>Propolis (isolement et purification)</term>
<term>Propolis (pharmacologie)</term>
<term>Relation dose-effet des médicaments (MeSH)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée ICR (MeSH)</term>
<term>Éthanol (composition chimique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents</term>
<term>Plant Extracts</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Ethanol</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Anti-Inflammatory Agents</term>
<term>Free Radical Scavengers</term>
<term>Plant Extracts</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term>
<term>Inflammation Mediators</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term>
<term>Free Radical Scavengers</term>
<term>Plant Extracts</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Lipopolysaccharides</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anti-inflammatoires</term>
<term>Extraits de plantes</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Endotoxémie</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Populus</term>
<term>Éthanol</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Endotoxemia</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Anti-inflammatoires</term>
<term>Extraits de plantes</term>
<term>Piégeurs de radicaux libres</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, High Pressure Liquid</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term>
<term>Médiateurs de l'inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Chromatographie en phase liquide à haute performance</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endotoxemia</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-inflammatoires</term>
<term>Extraits de plantes</term>
<term>Piégeurs de radicaux libres</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Lipopolysaccharides</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Endotoxémie</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Dose-Response Relationship, Drug</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred ICR</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules HEK293</term>
<term>Chine</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Mâle</term>
<term>Relation dose-effet des médicaments</term>
<term>Souris</term>
<term>Souris de lignée ICR</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>ETHNOPHARMACOLOGICAL RELEVANCE</b>
</p>
<p>Propolis is used widely in a number of cultures as a folk medicine and is gaining wider recognition for its potential therapeutic use, due to its wide range of biological properties and pharmacological activities, especially its anti-inflammatory effects. Despite an increasing number of studies focused on the biological activities of propolis together with its botanical sources, studies on Chinese propolis are insufficient. This study was designed to investigate the anti-inflammatory properties of ethanol extracts from Chinese propolis (EECP) and poplar buds (EEPB) from Populus×canadensis Moench (Salicaceae family).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b>
</p>
<p>Phytochemical analysis of EECP and EEPB was performed via total phenolic and flavonoid content measurements followed by high-performance liquid chromatography (HPLC) analysis. DPPH and ABTS free-radical scavenging methods were used to evaluate their anti-oxidant properties. The anti-inflammatory effects of EECP and EEPB were investigated in vitro by evaluating their modulating effects on the key inflammatory cytokines and mediators in LPS/IFN-γ co-stimulated RAW 264.7 cells and by measuring nuclear factor (NF)-κB activation in TNF-α or IL-1β stimulation HEK 293 cells using reporter gene assays. Their effects on acute inflammatory symptoms (LPS-induced endotoxemia and acute pulmonary damage) were also examined in mice.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>EECP and EEPB exhibited strong free-radical scavenging activity and significant in vitro anti-inflammatory effects by modulating key inflammatory mediators of mRNA transcription, inhibiting the production of specific inflammatory cytokines, and blocking the activation of nuclear factor (NF)-κB. The administration of EECP and EEPB (25 and 100 mg/kg) provided significant protective effects by attenuating lung histopathological changes and suppressing the secretion of LPS-stimulated inflammatory cytokines, such as interleukin-6 (IL-6), IL-10, MCP-1, TNF-α and IL-12p70 production in endotoxemic mice.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>The results presented here reveal the potent anti-inflammatory properties of Chinese propolis and poplar buds, and provide biological information for developing suitable substitute(s) for propolis in the prevention and treatment of inflammatory diseases.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24882729</PMID>
<DateCompleted><Year>2015</Year>
<Month>04</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>07</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>155</Volume>
<Issue>1</Issue>
<PubDate><Year>2014</Year>
<Month>Aug</Month>
<Day>08</Day>
</PubDate>
</JournalIssue>
<Title>Journal of ethnopharmacology</Title>
<ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation>
</Journal>
<ArticleTitle>Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis).</ArticleTitle>
<Pagination><MedlinePgn>300-11</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2014.05.037</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0378-8741(14)00406-1</ELocationID>
<Abstract><AbstractText Label="ETHNOPHARMACOLOGICAL RELEVANCE" NlmCategory="BACKGROUND">Propolis is used widely in a number of cultures as a folk medicine and is gaining wider recognition for its potential therapeutic use, due to its wide range of biological properties and pharmacological activities, especially its anti-inflammatory effects. Despite an increasing number of studies focused on the biological activities of propolis together with its botanical sources, studies on Chinese propolis are insufficient. This study was designed to investigate the anti-inflammatory properties of ethanol extracts from Chinese propolis (EECP) and poplar buds (EEPB) from Populus×canadensis Moench (Salicaceae family).</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Phytochemical analysis of EECP and EEPB was performed via total phenolic and flavonoid content measurements followed by high-performance liquid chromatography (HPLC) analysis. DPPH and ABTS free-radical scavenging methods were used to evaluate their anti-oxidant properties. The anti-inflammatory effects of EECP and EEPB were investigated in vitro by evaluating their modulating effects on the key inflammatory cytokines and mediators in LPS/IFN-γ co-stimulated RAW 264.7 cells and by measuring nuclear factor (NF)-κB activation in TNF-α or IL-1β stimulation HEK 293 cells using reporter gene assays. Their effects on acute inflammatory symptoms (LPS-induced endotoxemia and acute pulmonary damage) were also examined in mice.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">EECP and EEPB exhibited strong free-radical scavenging activity and significant in vitro anti-inflammatory effects by modulating key inflammatory mediators of mRNA transcription, inhibiting the production of specific inflammatory cytokines, and blocking the activation of nuclear factor (NF)-κB. The administration of EECP and EEPB (25 and 100 mg/kg) provided significant protective effects by attenuating lung histopathological changes and suppressing the secretion of LPS-stimulated inflammatory cytokines, such as interleukin-6 (IL-6), IL-10, MCP-1, TNF-α and IL-12p70 production in endotoxemic mice.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The results presented here reveal the potent anti-inflammatory properties of Chinese propolis and poplar buds, and provide biological information for developing suitable substitute(s) for propolis in the prevention and treatment of inflammatory diseases.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Kai</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Jianglin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ping</LastName>
<ForeName>Shun</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Quanxin</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Laboratory Animal Research Center, Zhejiang Chinese Medical University, Hangzhou 310053, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Xuan</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xuan</LastName>
<ForeName>Hongzhuan</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>School of Life Science, Liaocheng University, Liaocheng 252059, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Jinhu</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>College of Animal Sciences, Zhejiang University, Hangzhou 310058, China; Husbandry and veterinary technical popularization center of Zhejiang Province, Hangzhou 310020, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Cuiping</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Fuliang</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: flhu@zju.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>06</Month>
<Day>02</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Ireland</Country>
<MedlineTA>J Ethnopharmacol</MedlineTA>
<NlmUniqueID>7903310</NlmUniqueID>
<ISSNLinking>0378-8741</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016166">Free Radical Scavengers</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>3K9958V90M</RegistryNumber>
<NameOfSubstance UI="D000431">Ethanol</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9009-62-5</RegistryNumber>
<NameOfSubstance UI="D011429">Propolis</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019446" MajorTopicYN="N">Endotoxemia</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000431" MajorTopicYN="N">Ethanol</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016166" MajorTopicYN="N">Free Radical Scavengers</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008813" MajorTopicYN="N">Mice, Inbred ICR</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011429" MajorTopicYN="N">Propolis</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-inflammatory</Keyword>
<Keyword MajorTopicYN="N">Anti-oxidant</Keyword>
<Keyword MajorTopicYN="N">Chinese propolis</Keyword>
<Keyword MajorTopicYN="N">NF-κB</Keyword>
<Keyword MajorTopicYN="N">Poplar buds</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>02</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2014</Year>
<Month>05</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2014</Year>
<Month>05</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2014</Year>
<Month>6</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2014</Year>
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<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>4</Month>
<Day>8</Day>
<Hour>6</Hour>
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</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Zhejiang</li>
</region>
<settlement><li>Hangzhou</li>
</settlement>
<orgName><li>Université de Zhejiang</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name>
</region>
<name sortKey="Chen, Xuan" sort="Chen, Xuan" uniqKey="Chen X" first="Xuan" last="Chen">Xuan Chen</name>
<name sortKey="Hu, Fuliang" sort="Hu, Fuliang" uniqKey="Hu F" first="Fuliang" last="Hu">Fuliang Hu</name>
<name sortKey="Ma, Quanxin" sort="Ma, Quanxin" uniqKey="Ma Q" first="Quanxin" last="Ma">Quanxin Ma</name>
<name sortKey="Ping, Shun" sort="Ping, Shun" uniqKey="Ping S" first="Shun" last="Ping">Shun Ping</name>
<name sortKey="Shi, Jinhu" sort="Shi, Jinhu" uniqKey="Shi J" first="Jinhu" last="Shi">Jinhu Shi</name>
<name sortKey="Xuan, Hongzhuan" sort="Xuan, Hongzhuan" uniqKey="Xuan H" first="Hongzhuan" last="Xuan">Hongzhuan Xuan</name>
<name sortKey="Zhang, Cuiping" sort="Zhang, Cuiping" uniqKey="Zhang C" first="Cuiping" last="Zhang">Cuiping Zhang</name>
<name sortKey="Zhang, Jianglin" sort="Zhang, Jianglin" uniqKey="Zhang J" first="Jianglin" last="Zhang">Jianglin Zhang</name>
</country>
</tree>
</affiliations>
</record>

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Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis).

Anti-inflammatory effects of ethanol extracts of Chinese propolis and buds from poplar (Populus×canadensis).

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